Invited Speakers

Confirmed Invited Speakers

Session I. Biological effect of nanoparticles combined with photon or particle therapy

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Alexandre Detappe, PhD, PSRPM

Instructor in Medicine – Department of Medical Oncology, Dana-Farber Cancer Institute/Harvard Medical School
Visiting Scientist - David H Koch Institute for Integrative Cancer Research, MIT – Boston, United States

Talk: Nanoparticles for Enhanced Image-Guided Radiation Therapy in Pancreatic Cancer

 

Bio: Alexandre Detappe is a certified French medical physicist (PSRPM) who earned his MSc in medical physics at the University of Grenoble, France in 2013. In 2017, he obtained his PhD degree in the field of nanomedicine at the University of Lyon, France under the supervision of Prof. Olivier Tillement in collaboration with Dr. Ross Berbeco’s team in the department of radiation oncology of the Dana-Farber Cancer Institute/Brigham and Women’s Hospital/Harvard Medical School. His main research focus has been working on the development of a theranostic Gadolinium-based nanoparticle developed for MRI-guided radiation therapy for different cancer treatments, such as pancreatic adenocarcinoma.
Since the end of 2016, Alexandre Detappe joined the lab of Dr. Irene M. Ghobrial as Instructor in Medicine in the department of Medical Oncology at the Dana-Farber Cancer Institute/Harvard Medical School and the lab of Dr. Peter P. Ghoroghchian at the David H Koch Institute for Integrative Cancer Research at MIT to develop new theranostic approaches for Multiple Myeloma, including imaging biomarkers and new therapeutic solutions.

 

Session II. Elementary mechanisms and nanodosimetry

 

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Anatoly B. Rozenfeld, PhD

Distinguished Professor
Founder and Director - Centre for Medical Radiation Physics (CMRP), University of Wollongong - Wollongong, Australia

 

Bio: Distinguished Professor Anatoly  Rozenfeld  is the Founder and Director of Centre for Medical Radiation Physics (CMRP) at University of Wollongong,  which is the largest education and research multidisciplinary medical radiation physics  centre in Asia-Pacific with 18 academics and research only staff and more than 70 postgraduate students.

His scientific interest and expertise  is in the field of radiation semiconductor detectors development and their applications for  advanced medical radiation dosimetry and in conventional X-ray, synchrotron MRT  and particle radiation therapy and diagnostic radiology as well as for space radiation. Many radiation detectors developed at CMRP under his leadership were successfully implemented in practice of radiation oncology in Australia and overseas to improve confidence in cancer patient treatment with radiation.
 
Anatoly is Chair of International Solid State Dosimetry Organization (ISSDO) and Member of IEEE Radiation Instrumentation Steering Committee and General Chair of IEEE NSS MIC 2018.  He has initiated particle therapy research in Australia and is Member of National Particle Therapy Treatment and Research Centre Steering Committee . He published more than 300 peer review papers and holds 18 patents in the field of radiation detectors and dosimetry .

 

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Hans Rabus, PhD

Head of Department "Radiation Effects", Physikalisch-Technische Bundesanstalt (PTB) - Braunschweig, Germany

 

Talk: Nanodosimetry of nanoparticles - metrological aspects

 

Bio: Hans Rabus has been head of PTB department “Radiation Effects” (until 2015: “Fundamentals of Dosimetry”) since 2009. Together with his team he is pursuing research into the relation between ionizing particle track structure and biological effectiveness. Major activities are the development of experimental nanodosimetry in form of gas counters or DNA-based detectors, Monte Carlo code development for particle track structure simulations including measurement of relevant interaction cross section data, and radiobiological investigations using an ion micro beam allowing targeted irradiation of biological cells with defined number of particle tracks. From 2012-2015 Hans has been coordinator of the EMRP joint research project “BioQuaRT” which laid the foundations for novel radiation quantities that are better correlated with the biological effects of ionizing radiation. He is also chairing EURADOS task group 6.2 “Computational micro- and nanodosimetry” and has been on the management board of COST Action “Nanoscale Insights into Ion Beam cancer Therapy”.

 

Session III. Nanomaterials for radiation-based cancer therapies

 

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Ruxandra Gref, PhD

Director of Research - CNRS - Orsay, France

 

Bio: Ruxandra Gref carries on an interdisciplinary research at the frontier between polymer science, chemical engineering and pharmaceutical technology, mainly focused on the design of drug loaded core-shell nanoparticles to improve the treatment of severe diseases including cancer and microbial infections.
She teaches at a master degree in Paris-Sud University. She is part of the committee of the department of Chemistry in Paris Saclay, in charge with the interdisciplinary research at the interface chemistry-life sciences. Dr Gref is coordinating the “Cyclon Hit” Marie Curie Initial Training Network European project gathering 19 teams in Europe and US. She coordinates also a French ANR network “AntiTBnano” on the topic of engineered nanoparticles to treat tuberculosis.
Dr Gref is partner of a French major project dealing with the treatment of Staphylococcus aureus resistant infections and of an European project dealing with engineered nanoparticles to treat cancer.

 

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Sunil Krishnan, MD, FACP

Professor - John E. and Dorothy J. Harris
Director - Center for Radiation Oncology Research

Professor, Department of Radiation Oncology - MD Anderson Cancer Center - Houston, Texas

 

 

Bio: Dr. Krishnan is the Director of the Center for Radiation Oncology Research and the John E. and Dorothy J. Harris Professor of Gastrointestinal Cancer in the department of Radiation Oncology at MD Anderson Cancer Center. He received his medical degree from Christian Medical College, Vellore, India and completed a radiation oncology residency at Mayo Clinic, Rochester, Minnesota. In the clinic, he treats patients with hepatobiliary, pancreatic and rectal tumors with radiation therapy. His laboratory has developed new strategies and tools to define the roles and mechanisms of radiation sensitization with gold nanoparticles (hyperthermia and radiation dose enhancement), identified mechanisms to exploit this therapeutically, and developed techniques to facilitate imaging and image-guided therapy of cancers using nanoparticles. He has co-authored over 200 peer-reviewed scientific publications, co-authored 17 book chapters, and co-edited 3 books.

Session IV.  Simulations of radiation effects

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Jan Schuemann, PhD

Head of the Multi-Scale Monte Carlo Modeling Lab
Assistant Professor - Department of Radiation Oncology, Massachusetts General Hospital - Boston, United States

Talk: Can track structure simulations and mechanistic models predict the observed levels of (G)NP-induced radiosensitization?

 

Bio: After working in high-energy particle physics, Dr. Schuemann joined the field of medical physics as one of the core developers of the TOPAS (Tool for Particle Simulations) Monte Carlo toolkit. His research centers on using multi-disciplinary approaches to understand the mechanisms of cellular radiation response from initial DNA damage to biological effects. Dr. Schuemann is the head of the multi-scale Monte Carlo Modeling lab at MGH and leads the TOPAS-nBio developments, an extension of TOPAS for radiobiological experiments looking at sub-cellular structures and processes. He applies Monte Carlo simulation based models to investigate the effects of new therapy approaches, such as in using gold nanoparticles (GNPs) as radiosensitizers, and to understand how the observed sensitization of GNPs can be explained mechanistically.

 

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